Name	Flags	Card.	Type	Description & Constraints
ClinicalUseDefinition	C	0..*	ClinicalUseDefinition	CH IDMP ClincalUseDefinition Indication cud-1: Indication, Contraindication, Interaction, UndesirableEffect and Warning cannot be used in the same instance dom-2: If the resource is contained in another resource, it SHALL NOT contain nested Resources dom-3: If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource dom-4: If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated dom-5: If a resource is contained in another resource, it SHALL NOT have a security label dom-6: A resource should have narrative for robust management
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created ele-1: All FHIR elements must have a @value or children
contained		0..*	Resource	Contained, inline Resources
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
type	Σ	1..1	code	indication | contraindication | interaction | undesirable-effect | warning Binding: ClinicalUseDefinitionType (required): Overall defining type of this clinical use definition. ele-1: All FHIR elements must have a @value or children Required Pattern: indication
subject	Σ	0..*	Reference(IDMP MedicinalProductDefinition)	The medication, product, substance, device, procedure etc. for which this is an indication ele-1: All FHIR elements must have a @value or children
indication	ΣC	1..1	BackboneElement	Specifics for when this is an indication ele-1: All FHIR elements must have a @value or children
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
intendedEffect	Σ	0..1	CodeableReference(ObservationDefinition)	The intended effect, aim or strategy to be achieved Binding: EMA - Intended Effect (required) ele-1: All FHIR elements must have a @value or children
concept	Σ	1..1	CodeableConcept	Reference to a concept (by class) ele-1: All FHIR elements must have a @value or children
Slices for coding	Σ	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:system ele-1: All FHIR elements must have a @value or children
coding:SMC	Σ	0..1	Coding	Code defined by a terminology system ele-1: All FHIR elements must have a @value or children
system	Σ	1..1	uri	Identity of the terminology system ele-1: All FHIR elements must have a @value or children Required Pattern: http://spor.ema.europa.eu/v1/lists/200000003186
code	ΣC	1..1	code	Symbol in syntax defined by the system ele-1: All FHIR elements must have a @value or children
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
ClinicalUseDefinition.type	required	Pattern: indication http://hl7.org/fhir/ValueSet/clinical-use-definition-type|5.0.0 from the FHIR Standard
ClinicalUseDefinition.indication.intendedEffect	required	EMAIntendedEffectVS (a valid code from EMA - Intended Effect) http://fhir.ch/ig/ch-epl/ValueSet/ema-intended-effect from this IG

Constraints

Id	Grade	Path(s)	Details	Requirements
cud-1	error	ClinicalUseDefinition	Indication, Contraindication, Interaction, UndesirableEffect and Warning cannot be used in the same instance : (ClinicalUseDefinition.indication.count() + ClinicalUseDefinition.contraindication.count() + ClinicalUseDefinition.interaction.count() + ClinicalUseDefinition.undesirableEffect.count() + ClinicalUseDefinition.warning.count()) < 2
dom-2	error	ClinicalUseDefinition	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	ClinicalUseDefinition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	ClinicalUseDefinition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	ClinicalUseDefinition	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	ClinicalUseDefinition	A resource should have narrative for robust management : text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

Name	Flags	Card.	Type	Description & Constraints
ClinicalUseDefinition		0..*	ClinicalUseDefinition	CH IDMP ClincalUseDefinition Indication
type		1..1	code	indication | contraindication | interaction | undesirable-effect | warning Required Pattern: indication
subject		0..*	Reference(IDMP MedicinalProductDefinition)	The medication, product, substance, device, procedure etc. for which this is an indication
indication		1..1	BackboneElement	Specifics for when this is an indication
diseaseSymptomProcedure
concept		1..1	CodeableConcept	Reference to a concept (by class)
Slices for coding		1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:system
coding:SMC		0..1	Coding	Code defined by a terminology system
system		1..1	uri	Identity of the terminology system Required Pattern: https://www.meddra.org
code		1..1	code	Symbol in syntax defined by the system
coding:FOPH		0..1	Coding	Code defined by a terminology system
system		1..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
code		1..1	code	Symbol in syntax defined by the system
comorbidity
concept		1..1	CodeableConcept	Reference to a concept (by class)
Slices for coding		1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:system
coding:SMC		0..1	Coding	Code defined by a terminology system
system		1..1	uri	Identity of the terminology system Required Pattern: https://www.meddra.org
code		1..1	code	Symbol in syntax defined by the system
coding:FOPH		0..1	Coding	Code defined by a terminology system
system		1..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
code		1..1	code	Symbol in syntax defined by the system
intendedEffect		0..1	CodeableReference(ObservationDefinition)	The intended effect, aim or strategy to be achieved Binding: EMA - Intended Effect (required)
concept		1..1	CodeableConcept	Reference to a concept (by class)
Slices for coding		1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:system
coding:SMC		0..1	Coding	Code defined by a terminology system
system		1..1	uri	Identity of the terminology system Required Pattern: http://spor.ema.europa.eu/v1/lists/200000003186
code		1..1	code	Symbol in syntax defined by the system
Documentation for this format

Terminology Bindings (Differential)

Path	Conformance	ValueSet	URI
ClinicalUseDefinition.indication.intendedEffect	required	EMAIntendedEffectVS (a valid code from EMA - Intended Effect) http://fhir.ch/ig/ch-epl/ValueSet/ema-intended-effect from this IG

Name	Flags	Card.	Type	Description & Constraints
ClinicalUseDefinition	C	0..*	ClinicalUseDefinition	CH IDMP ClincalUseDefinition Indication cud-1: Indication, Contraindication, Interaction, UndesirableEffect and Warning cannot be used in the same instance
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter
text		0..1	Narrative	Text summary of the resource, for human interpretation
contained		0..*	Resource	Contained, inline Resources
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
identifier	Σ	0..*	Identifier	Business identifier for this issue
type	Σ	1..1	code	indication | contraindication | interaction | undesirable-effect | warning Binding: ClinicalUseDefinitionType (required): Overall defining type of this clinical use definition. Required Pattern: indication
category	Σ	0..*	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose" Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
subject	Σ	0..*	Reference(IDMP MedicinalProductDefinition)	The medication, product, substance, device, procedure etc. for which this is an indication
status	Σ	0..1	CodeableConcept	Whether this is a current issue or one that has been retired etc Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
contraindication	ΣC	0..1	BackboneElement	Specifics for when this is a contraindication
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
diseaseSymptomProcedure	Σ	0..1	CodeableReference(ObservationDefinition)	The situation that is being documented as contraindicating against this item Binding: DiseaseSymptomProcedure (example): A symptom, disease or procedure.
diseaseStatus	Σ	0..1	CodeableReference(ObservationDefinition)	The status of the disease or symptom for the contraindication Binding: DiseaseStatus (example): The status of a disease or symptom.
comorbidity	Σ	0..*	CodeableReference(ObservationDefinition)	A comorbidity (concurrent condition) or coinfection Binding: DiseaseSymptomProcedure (example): A symptom, disease or procedure.
indication	Σ	0..*	Reference(ClinicalUseDefinition)	The indication which this is a contraidication for
applicability		0..1	Expression	An expression that returns true or false, indicating whether the indication is applicable or not, after having applied its other elements
otherTherapy	Σ	0..*	BackboneElement	Information about use of the product in relation to other therapies described as part of the contraindication
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
relationshipType	Σ	1..1	CodeableConcept	The type of relationship between the product indication/contraindication and another therapy Binding: TherapyRelationshipType (preferred): Classification of relationship between a therapy and a contraindication or an indication.
treatment	Σ	1..1	CodeableReference(MedicinalProductDefinition | Medication | Substance | SubstanceDefinition | NutritionProduct | BiologicallyDerivedProduct | ActivityDefinition)	Reference to a specific medication, substance etc. as part of an indication or contraindication Binding: Therapy (example): A therapy.
indication	ΣC	1..1	BackboneElement	Specifics for when this is an indication
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
diseaseSymptomProcedure	Σ	0..1	CodeableReference(ObservationDefinition)	The situation that is being documented as an indicaton for this item Binding: DiseaseSymptomProcedure (example): A symptom, disease or procedure.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
concept	Σ	1..1	CodeableConcept	Reference to a concept (by class)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Slices for coding	Σ	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:system
coding:SMC	Σ	0..1	Coding	Code defined by a terminology system
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	Σ	1..1	uri	Identity of the terminology system Required Pattern: https://www.meddra.org
version	Σ	0..1	string	Version of the system - if relevant
code	ΣC	1..1	code	Symbol in syntax defined by the system
display	ΣC	0..1	string	Representation defined by the system
userSelected	Σ	0..1	boolean	If this coding was chosen directly by the user
coding:FOPH	Σ	0..1	Coding	Code defined by a terminology system
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	Σ	1..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
version	Σ	0..1	string	Version of the system - if relevant
code	ΣC	1..1	code	Symbol in syntax defined by the system
display	ΣC	0..1	string	Representation defined by the system
userSelected	Σ	0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
reference	Σ	0..1	Reference()	Reference to a resource (by instance)
diseaseStatus	Σ	0..1	CodeableReference(ObservationDefinition)	The status of the disease or symptom for the indication Binding: DiseaseStatus (example): The status of a disease or symptom.
comorbidity	Σ	0..*	CodeableReference(ObservationDefinition)	A comorbidity or coinfection as part of the indication Binding: DiseaseSymptomProcedure (example): A symptom, disease or procedure.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
concept	Σ	1..1	CodeableConcept	Reference to a concept (by class)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Slices for coding	Σ	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:system
coding:SMC	Σ	0..1	Coding	Code defined by a terminology system
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	Σ	1..1	uri	Identity of the terminology system Required Pattern: https://www.meddra.org
version	Σ	0..1	string	Version of the system - if relevant
code	ΣC	1..1	code	Symbol in syntax defined by the system
display	ΣC	0..1	string	Representation defined by the system
userSelected	Σ	0..1	boolean	If this coding was chosen directly by the user
coding:FOPH	Σ	0..1	Coding	Code defined by a terminology system
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	Σ	1..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
version	Σ	0..1	string	Version of the system - if relevant
code	ΣC	1..1	code	Symbol in syntax defined by the system
display	ΣC	0..1	string	Representation defined by the system
userSelected	Σ	0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
reference	Σ	0..1	Reference()	Reference to a resource (by instance)
intendedEffect	Σ	0..1	CodeableReference(ObservationDefinition)	The intended effect, aim or strategy to be achieved Binding: EMA - Intended Effect (required)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
concept	Σ	1..1	CodeableConcept	Reference to a concept (by class)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Slices for coding	Σ	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:system
coding:SMC	Σ	0..1	Coding	Code defined by a terminology system
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	Σ	1..1	uri	Identity of the terminology system Required Pattern: http://spor.ema.europa.eu/v1/lists/200000003186
version	Σ	0..1	string	Version of the system - if relevant
code	ΣC	1..1	code	Symbol in syntax defined by the system
display	ΣC	0..1	string	Representation defined by the system
userSelected	Σ	0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
reference	Σ	0..1	Reference()	Reference to a resource (by instance)
duration[x]	Σ	0..1		Timing or duration information
durationRange			Range
durationString			string
undesirableEffect	Σ	0..*	Reference(ClinicalUseDefinition)	An unwanted side effect or negative outcome of the subject of this resource when being used for this indication
applicability		0..1	Expression	An expression that returns true or false, indicating whether the indication is applicable or not, after having applied its other elements
otherTherapy	Σ	0..*	See otherTherapy (ClinicalUseDefinition)	The use of the medicinal product in relation to other therapies described as part of the indication
interaction	ΣC	0..1	BackboneElement	Specifics for when this is an interaction
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
interactant	Σ	0..*	BackboneElement	The specific medication, product, food etc. or laboratory test that interacts
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
item[x]	Σ	1..1		The specific medication, product, food etc. or laboratory test that interacts Binding: Interactant (example): An interactant - a substance that may have a clinically significant effect on another.
itemReference			Reference(MedicinalProductDefinition | Medication | Substance | NutritionProduct | BiologicallyDerivedProduct | ObservationDefinition)
itemCodeableConcept			CodeableConcept
type	Σ	0..1	CodeableConcept	The type of the interaction e.g. drug-drug interaction, drug-lab test interaction Binding: InteractionType (example): A categorisation for an interaction between two substances.
effect	Σ	0..1	CodeableReference(ObservationDefinition)	The effect of the interaction, for example "reduced gastric absorption of primary medication" Binding: InteractionEffect (example): A interaction effect of clinical use of a medication or other substance.
incidence	Σ	0..1	CodeableConcept	The incidence of the interaction, e.g. theoretical, observed Binding: InteractionIncidence (example): A categorisation for incidence of occurence of an interaction.
management	Σ	0..*	CodeableConcept	Actions for managing the interaction Binding: InteractionManagement (example): A type of management for an interaction of a medication or other substance.
population	Σ	0..*	Reference(Group)	The population group to which this applies
library	Σ	0..*	canonical(Library)	Logic used by the clinical use definition
undesirableEffect	ΣC	0..1	BackboneElement	A possible negative outcome from the use of this treatment
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
symptomConditionEffect	Σ	0..1	CodeableReference(ObservationDefinition)	The situation in which the undesirable effect may manifest Binding: UndesirableEffectSymptom (example): An undesirable effect of clinical use.
classification	Σ	0..1	CodeableConcept	High level classification of the effect Binding: UndesirableEffectClassification (example): A categorisation for an undesirable effect.
frequencyOfOccurrence	Σ	0..1	CodeableConcept	How often the effect is seen Binding: UndesirablEffectFrequency (example): A categorisation for a frequency of occurence of an undesirable effect.
warning	ΣC	0..1	BackboneElement	Critical environmental, health or physical risks or hazards. For example 'Do not operate heavy machinery', 'May cause drowsiness'
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description	Σ	0..1	markdown	A textual definition of this warning, with formatting
code	Σ	0..1	CodeableConcept	A coded or unformatted textual definition of this warning Binding: WarningType (example): Classification of warning type.
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
ClinicalUseDefinition.language	required	AllLanguages http://hl7.org/fhir/ValueSet/all-languages|5.0.0 from the FHIR Standard
ClinicalUseDefinition.type	required	Pattern: indication http://hl7.org/fhir/ValueSet/clinical-use-definition-type|5.0.0 from the FHIR Standard
ClinicalUseDefinition.category	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category from the FHIR Standard
ClinicalUseDefinition.status	preferred	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status from the FHIR Standard
ClinicalUseDefinition.contraindication.diseaseSymptomProcedure	example	DiseaseSymptomProcedure http://hl7.org/fhir/ValueSet/disease-symptom-procedure from the FHIR Standard
ClinicalUseDefinition.contraindication.diseaseStatus	example	DiseaseStatus http://hl7.org/fhir/ValueSet/disease-status from the FHIR Standard
ClinicalUseDefinition.contraindication.comorbidity	example	DiseaseSymptomProcedure http://hl7.org/fhir/ValueSet/disease-symptom-procedure from the FHIR Standard
ClinicalUseDefinition.contraindication.otherTherapy.relationshipType	preferred	TherapyRelationshipType http://hl7.org/fhir/ValueSet/therapy-relationship-type from the FHIR Standard
ClinicalUseDefinition.contraindication.otherTherapy.treatment	example	Therapy http://hl7.org/fhir/ValueSet/therapy from the FHIR Standard
ClinicalUseDefinition.indication.diseaseSymptomProcedure	example	DiseaseSymptomProcedure http://hl7.org/fhir/ValueSet/disease-symptom-procedure from the FHIR Standard
ClinicalUseDefinition.indication.diseaseStatus	example	DiseaseStatus http://hl7.org/fhir/ValueSet/disease-status from the FHIR Standard
ClinicalUseDefinition.indication.comorbidity	example	DiseaseSymptomProcedure http://hl7.org/fhir/ValueSet/disease-symptom-procedure from the FHIR Standard
ClinicalUseDefinition.indication.intendedEffect	required	EMAIntendedEffectVS (a valid code from EMA - Intended Effect) http://fhir.ch/ig/ch-epl/ValueSet/ema-intended-effect from this IG
ClinicalUseDefinition.interaction.interactant.item[x]	example	Interactant http://hl7.org/fhir/ValueSet/interactant from the FHIR Standard
ClinicalUseDefinition.interaction.type	example	InteractionType http://hl7.org/fhir/ValueSet/interaction-type from the FHIR Standard
ClinicalUseDefinition.interaction.effect	example	InteractionEffect http://hl7.org/fhir/ValueSet/interaction-effect from the FHIR Standard
ClinicalUseDefinition.interaction.incidence	example	InteractionIncidence http://hl7.org/fhir/ValueSet/interaction-incidence from the FHIR Standard
ClinicalUseDefinition.interaction.management	example	InteractionManagement http://hl7.org/fhir/ValueSet/interaction-management from the FHIR Standard
ClinicalUseDefinition.undesirableEffect.symptomConditionEffect	example	UndesirableEffectSymptom http://hl7.org/fhir/ValueSet/undesirable-effect-symptom from the FHIR Standard
ClinicalUseDefinition.undesirableEffect.classification	example	UndesirableEffectClassification http://hl7.org/fhir/ValueSet/undesirable-effect-classification from the FHIR Standard
ClinicalUseDefinition.undesirableEffect.frequencyOfOccurrence	example	UndesirablEffectFrequency http://hl7.org/fhir/ValueSet/undesirable-effect-frequency from the FHIR Standard
ClinicalUseDefinition.warning.code	example	WarningType http://hl7.org/fhir/ValueSet/warning-type from the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cud-1	error	ClinicalUseDefinition	Indication, Contraindication, Interaction, UndesirableEffect and Warning cannot be used in the same instance : (ClinicalUseDefinition.indication.count() + ClinicalUseDefinition.contraindication.count() + ClinicalUseDefinition.interaction.count() + ClinicalUseDefinition.undesirableEffect.count() + ClinicalUseDefinition.warning.count()) < 2
dom-2	error	ClinicalUseDefinition	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	ClinicalUseDefinition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	ClinicalUseDefinition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	ClinicalUseDefinition	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	ClinicalUseDefinition	A resource should have narrative for robust management : text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

Summary

Mandatory: 1 element(16 nested mandatory elements)

Structures

This structure refers to these other structures:

• IDMP MedicinalProductDefinition (http://fhir.ch/ig/ch-epl/StructureDefinition/ch-idmp-medicinalproductdefinition)

Slices

This structure defines the following Slices:

• The element 1 is sliced based on the value of ClinicalUseDefinition.indication.diseaseSymptomProcedure.concept.coding
• The element 1 is sliced based on the value of ClinicalUseDefinition.indication.comorbidity.concept.coding
• The element 1 is sliced based on the value of ClinicalUseDefinition.indication.intendedEffect.concept.coding

Name	Flags	Card.	Type	Description & Constraints
ClinicalUseDefinition	C	0..*	ClinicalUseDefinition	CH IDMP ClincalUseDefinition Indication cud-1: Indication, Contraindication, Interaction, UndesirableEffect and Warning cannot be used in the same instance dom-2: If the resource is contained in another resource, it SHALL NOT contain nested Resources dom-3: If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource dom-4: If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated dom-5: If a resource is contained in another resource, it SHALL NOT have a security label dom-6: A resource should have narrative for robust management
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created ele-1: All FHIR elements must have a @value or children
contained		0..*	Resource	Contained, inline Resources
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
type	Σ	1..1	code	indication | contraindication | interaction | undesirable-effect | warning Binding: ClinicalUseDefinitionType (required): Overall defining type of this clinical use definition. ele-1: All FHIR elements must have a @value or children Required Pattern: indication
subject	Σ	0..*	Reference(IDMP MedicinalProductDefinition)	The medication, product, substance, device, procedure etc. for which this is an indication ele-1: All FHIR elements must have a @value or children
indication	ΣC	1..1	BackboneElement	Specifics for when this is an indication ele-1: All FHIR elements must have a @value or children
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized ele-1: All FHIR elements must have a @value or children ext-1: Must have either extensions or value[x], not both
intendedEffect	Σ	0..1	CodeableReference(ObservationDefinition)	The intended effect, aim or strategy to be achieved Binding: EMA - Intended Effect (required) ele-1: All FHIR elements must have a @value or children
concept	Σ	1..1	CodeableConcept	Reference to a concept (by class) ele-1: All FHIR elements must have a @value or children
Slices for coding	Σ	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:system ele-1: All FHIR elements must have a @value or children
coding:SMC	Σ	0..1	Coding	Code defined by a terminology system ele-1: All FHIR elements must have a @value or children
system	Σ	1..1	uri	Identity of the terminology system ele-1: All FHIR elements must have a @value or children Required Pattern: http://spor.ema.europa.eu/v1/lists/200000003186
code	ΣC	1..1	code	Symbol in syntax defined by the system ele-1: All FHIR elements must have a @value or children
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
ClinicalUseDefinition.type	required	Pattern: indication http://hl7.org/fhir/ValueSet/clinical-use-definition-type|5.0.0 from the FHIR Standard
ClinicalUseDefinition.indication.intendedEffect	required	EMAIntendedEffectVS (a valid code from EMA - Intended Effect) http://fhir.ch/ig/ch-epl/ValueSet/ema-intended-effect from this IG

Constraints

Id	Grade	Path(s)	Details	Requirements
cud-1	error	ClinicalUseDefinition	Indication, Contraindication, Interaction, UndesirableEffect and Warning cannot be used in the same instance : (ClinicalUseDefinition.indication.count() + ClinicalUseDefinition.contraindication.count() + ClinicalUseDefinition.interaction.count() + ClinicalUseDefinition.undesirableEffect.count() + ClinicalUseDefinition.warning.count()) < 2
dom-2	error	ClinicalUseDefinition	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	ClinicalUseDefinition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	ClinicalUseDefinition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	ClinicalUseDefinition	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	ClinicalUseDefinition	A resource should have narrative for robust management : text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

Name	Flags	Card.	Type	Description & Constraints
ClinicalUseDefinition		0..*	ClinicalUseDefinition	CH IDMP ClincalUseDefinition Indication
type		1..1	code	indication | contraindication | interaction | undesirable-effect | warning Required Pattern: indication
subject		0..*	Reference(IDMP MedicinalProductDefinition)	The medication, product, substance, device, procedure etc. for which this is an indication
indication		1..1	BackboneElement	Specifics for when this is an indication
diseaseSymptomProcedure
concept		1..1	CodeableConcept	Reference to a concept (by class)
Slices for coding		1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:system
coding:SMC		0..1	Coding	Code defined by a terminology system
system		1..1	uri	Identity of the terminology system Required Pattern: https://www.meddra.org
code		1..1	code	Symbol in syntax defined by the system
coding:FOPH		0..1	Coding	Code defined by a terminology system
system		1..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
code		1..1	code	Symbol in syntax defined by the system
comorbidity
concept		1..1	CodeableConcept	Reference to a concept (by class)
Slices for coding		1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:system
coding:SMC		0..1	Coding	Code defined by a terminology system
system		1..1	uri	Identity of the terminology system Required Pattern: https://www.meddra.org
code		1..1	code	Symbol in syntax defined by the system
coding:FOPH		0..1	Coding	Code defined by a terminology system
system		1..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
code		1..1	code	Symbol in syntax defined by the system
intendedEffect		0..1	CodeableReference(ObservationDefinition)	The intended effect, aim or strategy to be achieved Binding: EMA - Intended Effect (required)
concept		1..1	CodeableConcept	Reference to a concept (by class)
Slices for coding		1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:system
coding:SMC		0..1	Coding	Code defined by a terminology system
system		1..1	uri	Identity of the terminology system Required Pattern: http://spor.ema.europa.eu/v1/lists/200000003186
code		1..1	code	Symbol in syntax defined by the system
Documentation for this format

Terminology Bindings (Differential)

Path	Conformance	ValueSet	URI
ClinicalUseDefinition.indication.intendedEffect	required	EMAIntendedEffectVS (a valid code from EMA - Intended Effect) http://fhir.ch/ig/ch-epl/ValueSet/ema-intended-effect from this IG

Name	Flags	Card.	Type	Description & Constraints
ClinicalUseDefinition	C	0..*	ClinicalUseDefinition	CH IDMP ClincalUseDefinition Indication cud-1: Indication, Contraindication, Interaction, UndesirableEffect and Warning cannot be used in the same instance
id	Σ	0..1	id	Logical id of this artifact
meta	Σ	0..1	Meta	Metadata about the resource
implicitRules	?!Σ	0..1	uri	A set of rules under which this content was created
language		0..1	code	Language of the resource content Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter
text		0..1	Narrative	Text summary of the resource, for human interpretation
contained		0..*	Resource	Contained, inline Resources
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored
identifier	Σ	0..*	Identifier	Business identifier for this issue
type	Σ	1..1	code	indication | contraindication | interaction | undesirable-effect | warning Binding: ClinicalUseDefinitionType (required): Overall defining type of this clinical use definition. Required Pattern: indication
category	Σ	0..*	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose" Binding: ClinicalUseDefinitionCategory (preferred): A categorisation for a clinical use information item.
subject	Σ	0..*	Reference(IDMP MedicinalProductDefinition)	The medication, product, substance, device, procedure etc. for which this is an indication
status	Σ	0..1	CodeableConcept	Whether this is a current issue or one that has been retired etc Binding: PublicationStatus (preferred): The lifecycle status of an artifact.
contraindication	ΣC	0..1	BackboneElement	Specifics for when this is a contraindication
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
diseaseSymptomProcedure	Σ	0..1	CodeableReference(ObservationDefinition)	The situation that is being documented as contraindicating against this item Binding: DiseaseSymptomProcedure (example): A symptom, disease or procedure.
diseaseStatus	Σ	0..1	CodeableReference(ObservationDefinition)	The status of the disease or symptom for the contraindication Binding: DiseaseStatus (example): The status of a disease or symptom.
comorbidity	Σ	0..*	CodeableReference(ObservationDefinition)	A comorbidity (concurrent condition) or coinfection Binding: DiseaseSymptomProcedure (example): A symptom, disease or procedure.
indication	Σ	0..*	Reference(ClinicalUseDefinition)	The indication which this is a contraidication for
applicability		0..1	Expression	An expression that returns true or false, indicating whether the indication is applicable or not, after having applied its other elements
otherTherapy	Σ	0..*	BackboneElement	Information about use of the product in relation to other therapies described as part of the contraindication
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
relationshipType	Σ	1..1	CodeableConcept	The type of relationship between the product indication/contraindication and another therapy Binding: TherapyRelationshipType (preferred): Classification of relationship between a therapy and a contraindication or an indication.
treatment	Σ	1..1	CodeableReference(MedicinalProductDefinition | Medication | Substance | SubstanceDefinition | NutritionProduct | BiologicallyDerivedProduct | ActivityDefinition)	Reference to a specific medication, substance etc. as part of an indication or contraindication Binding: Therapy (example): A therapy.
indication	ΣC	1..1	BackboneElement	Specifics for when this is an indication
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
diseaseSymptomProcedure	Σ	0..1	CodeableReference(ObservationDefinition)	The situation that is being documented as an indicaton for this item Binding: DiseaseSymptomProcedure (example): A symptom, disease or procedure.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
concept	Σ	1..1	CodeableConcept	Reference to a concept (by class)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Slices for coding	Σ	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:system
coding:SMC	Σ	0..1	Coding	Code defined by a terminology system
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	Σ	1..1	uri	Identity of the terminology system Required Pattern: https://www.meddra.org
version	Σ	0..1	string	Version of the system - if relevant
code	ΣC	1..1	code	Symbol in syntax defined by the system
display	ΣC	0..1	string	Representation defined by the system
userSelected	Σ	0..1	boolean	If this coding was chosen directly by the user
coding:FOPH	Σ	0..1	Coding	Code defined by a terminology system
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	Σ	1..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
version	Σ	0..1	string	Version of the system - if relevant
code	ΣC	1..1	code	Symbol in syntax defined by the system
display	ΣC	0..1	string	Representation defined by the system
userSelected	Σ	0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
reference	Σ	0..1	Reference()	Reference to a resource (by instance)
diseaseStatus	Σ	0..1	CodeableReference(ObservationDefinition)	The status of the disease or symptom for the indication Binding: DiseaseStatus (example): The status of a disease or symptom.
comorbidity	Σ	0..*	CodeableReference(ObservationDefinition)	A comorbidity or coinfection as part of the indication Binding: DiseaseSymptomProcedure (example): A symptom, disease or procedure.
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
concept	Σ	1..1	CodeableConcept	Reference to a concept (by class)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Slices for coding	Σ	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:system
coding:SMC	Σ	0..1	Coding	Code defined by a terminology system
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	Σ	1..1	uri	Identity of the terminology system Required Pattern: https://www.meddra.org
version	Σ	0..1	string	Version of the system - if relevant
code	ΣC	1..1	code	Symbol in syntax defined by the system
display	ΣC	0..1	string	Representation defined by the system
userSelected	Σ	0..1	boolean	If this coding was chosen directly by the user
coding:FOPH	Σ	0..1	Coding	Code defined by a terminology system
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	Σ	1..1	uri	Identity of the terminology system Required Pattern: http://snomed.info/sct
version	Σ	0..1	string	Version of the system - if relevant
code	ΣC	1..1	code	Symbol in syntax defined by the system
display	ΣC	0..1	string	Representation defined by the system
userSelected	Σ	0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
reference	Σ	0..1	Reference()	Reference to a resource (by instance)
intendedEffect	Σ	0..1	CodeableReference(ObservationDefinition)	The intended effect, aim or strategy to be achieved Binding: EMA - Intended Effect (required)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
concept	Σ	1..1	CodeableConcept	Reference to a concept (by class)
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Slices for coding	Σ	1..*	Coding	Code defined by a terminology system Slice: Unordered, Open by value:system
coding:SMC	Σ	0..1	Coding	Code defined by a terminology system
id		0..1	id	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
system	Σ	1..1	uri	Identity of the terminology system Required Pattern: http://spor.ema.europa.eu/v1/lists/200000003186
version	Σ	0..1	string	Version of the system - if relevant
code	ΣC	1..1	code	Symbol in syntax defined by the system
display	ΣC	0..1	string	Representation defined by the system
userSelected	Σ	0..1	boolean	If this coding was chosen directly by the user
text	Σ	0..1	string	Plain text representation of the concept
reference	Σ	0..1	Reference()	Reference to a resource (by instance)
duration[x]	Σ	0..1		Timing or duration information
durationRange			Range
durationString			string
undesirableEffect	Σ	0..*	Reference(ClinicalUseDefinition)	An unwanted side effect or negative outcome of the subject of this resource when being used for this indication
applicability		0..1	Expression	An expression that returns true or false, indicating whether the indication is applicable or not, after having applied its other elements
otherTherapy	Σ	0..*	See otherTherapy (ClinicalUseDefinition)	The use of the medicinal product in relation to other therapies described as part of the indication
interaction	ΣC	0..1	BackboneElement	Specifics for when this is an interaction
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
interactant	Σ	0..*	BackboneElement	The specific medication, product, food etc. or laboratory test that interacts
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
item[x]	Σ	1..1		The specific medication, product, food etc. or laboratory test that interacts Binding: Interactant (example): An interactant - a substance that may have a clinically significant effect on another.
itemReference			Reference(MedicinalProductDefinition | Medication | Substance | NutritionProduct | BiologicallyDerivedProduct | ObservationDefinition)
itemCodeableConcept			CodeableConcept
type	Σ	0..1	CodeableConcept	The type of the interaction e.g. drug-drug interaction, drug-lab test interaction Binding: InteractionType (example): A categorisation for an interaction between two substances.
effect	Σ	0..1	CodeableReference(ObservationDefinition)	The effect of the interaction, for example "reduced gastric absorption of primary medication" Binding: InteractionEffect (example): A interaction effect of clinical use of a medication or other substance.
incidence	Σ	0..1	CodeableConcept	The incidence of the interaction, e.g. theoretical, observed Binding: InteractionIncidence (example): A categorisation for incidence of occurence of an interaction.
management	Σ	0..*	CodeableConcept	Actions for managing the interaction Binding: InteractionManagement (example): A type of management for an interaction of a medication or other substance.
population	Σ	0..*	Reference(Group)	The population group to which this applies
library	Σ	0..*	canonical(Library)	Logic used by the clinical use definition
undesirableEffect	ΣC	0..1	BackboneElement	A possible negative outcome from the use of this treatment
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
symptomConditionEffect	Σ	0..1	CodeableReference(ObservationDefinition)	The situation in which the undesirable effect may manifest Binding: UndesirableEffectSymptom (example): An undesirable effect of clinical use.
classification	Σ	0..1	CodeableConcept	High level classification of the effect Binding: UndesirableEffectClassification (example): A categorisation for an undesirable effect.
frequencyOfOccurrence	Σ	0..1	CodeableConcept	How often the effect is seen Binding: UndesirablEffectFrequency (example): A categorisation for a frequency of occurence of an undesirable effect.
warning	ΣC	0..1	BackboneElement	Critical environmental, health or physical risks or hazards. For example 'Do not operate heavy machinery', 'May cause drowsiness'
id		0..1	string	Unique id for inter-element referencing
extension		0..*	Extension	Additional content defined by implementations
modifierExtension	?!Σ	0..*	Extension	Extensions that cannot be ignored even if unrecognized
description	Σ	0..1	markdown	A textual definition of this warning, with formatting
code	Σ	0..1	CodeableConcept	A coded or unformatted textual definition of this warning Binding: WarningType (example): Classification of warning type.
Documentation for this format

Terminology Bindings

Path	Conformance	ValueSet / Code	URI
ClinicalUseDefinition.language	required	AllLanguages http://hl7.org/fhir/ValueSet/all-languages|5.0.0 from the FHIR Standard
ClinicalUseDefinition.type	required	Pattern: indication http://hl7.org/fhir/ValueSet/clinical-use-definition-type|5.0.0 from the FHIR Standard
ClinicalUseDefinition.category	preferred	ClinicalUseDefinitionCategory http://hl7.org/fhir/ValueSet/clinical-use-definition-category from the FHIR Standard
ClinicalUseDefinition.status	preferred	PublicationStatus http://hl7.org/fhir/ValueSet/publication-status from the FHIR Standard
ClinicalUseDefinition.contraindication.diseaseSymptomProcedure	example	DiseaseSymptomProcedure http://hl7.org/fhir/ValueSet/disease-symptom-procedure from the FHIR Standard
ClinicalUseDefinition.contraindication.diseaseStatus	example	DiseaseStatus http://hl7.org/fhir/ValueSet/disease-status from the FHIR Standard
ClinicalUseDefinition.contraindication.comorbidity	example	DiseaseSymptomProcedure http://hl7.org/fhir/ValueSet/disease-symptom-procedure from the FHIR Standard
ClinicalUseDefinition.contraindication.otherTherapy.relationshipType	preferred	TherapyRelationshipType http://hl7.org/fhir/ValueSet/therapy-relationship-type from the FHIR Standard
ClinicalUseDefinition.contraindication.otherTherapy.treatment	example	Therapy http://hl7.org/fhir/ValueSet/therapy from the FHIR Standard
ClinicalUseDefinition.indication.diseaseSymptomProcedure	example	DiseaseSymptomProcedure http://hl7.org/fhir/ValueSet/disease-symptom-procedure from the FHIR Standard
ClinicalUseDefinition.indication.diseaseStatus	example	DiseaseStatus http://hl7.org/fhir/ValueSet/disease-status from the FHIR Standard
ClinicalUseDefinition.indication.comorbidity	example	DiseaseSymptomProcedure http://hl7.org/fhir/ValueSet/disease-symptom-procedure from the FHIR Standard
ClinicalUseDefinition.indication.intendedEffect	required	EMAIntendedEffectVS (a valid code from EMA - Intended Effect) http://fhir.ch/ig/ch-epl/ValueSet/ema-intended-effect from this IG
ClinicalUseDefinition.interaction.interactant.item[x]	example	Interactant http://hl7.org/fhir/ValueSet/interactant from the FHIR Standard
ClinicalUseDefinition.interaction.type	example	InteractionType http://hl7.org/fhir/ValueSet/interaction-type from the FHIR Standard
ClinicalUseDefinition.interaction.effect	example	InteractionEffect http://hl7.org/fhir/ValueSet/interaction-effect from the FHIR Standard
ClinicalUseDefinition.interaction.incidence	example	InteractionIncidence http://hl7.org/fhir/ValueSet/interaction-incidence from the FHIR Standard
ClinicalUseDefinition.interaction.management	example	InteractionManagement http://hl7.org/fhir/ValueSet/interaction-management from the FHIR Standard
ClinicalUseDefinition.undesirableEffect.symptomConditionEffect	example	UndesirableEffectSymptom http://hl7.org/fhir/ValueSet/undesirable-effect-symptom from the FHIR Standard
ClinicalUseDefinition.undesirableEffect.classification	example	UndesirableEffectClassification http://hl7.org/fhir/ValueSet/undesirable-effect-classification from the FHIR Standard
ClinicalUseDefinition.undesirableEffect.frequencyOfOccurrence	example	UndesirablEffectFrequency http://hl7.org/fhir/ValueSet/undesirable-effect-frequency from the FHIR Standard
ClinicalUseDefinition.warning.code	example	WarningType http://hl7.org/fhir/ValueSet/warning-type from the FHIR Standard

Constraints

Id	Grade	Path(s)	Details	Requirements
cud-1	error	ClinicalUseDefinition	Indication, Contraindication, Interaction, UndesirableEffect and Warning cannot be used in the same instance : (ClinicalUseDefinition.indication.count() + ClinicalUseDefinition.contraindication.count() + ClinicalUseDefinition.interaction.count() + ClinicalUseDefinition.undesirableEffect.count() + ClinicalUseDefinition.warning.count()) < 2
dom-2	error	ClinicalUseDefinition	If the resource is contained in another resource, it SHALL NOT contain nested Resources : contained.contained.empty()
dom-3	error	ClinicalUseDefinition	If the resource is contained in another resource, it SHALL be referred to from elsewhere in the resource or SHALL refer to the containing resource : contained.where((('#'+id in (%resource.descendants().reference | %resource.descendants().ofType(canonical) | %resource.descendants().ofType(uri) | %resource.descendants().ofType(url))) or descendants().where(reference = '#').exists() or descendants().where(ofType(canonical) = '#').exists() or descendants().where(ofType(canonical) = '#').exists()).not()).trace('unmatched', id).empty()
dom-4	error	ClinicalUseDefinition	If a resource is contained in another resource, it SHALL NOT have a meta.versionId or a meta.lastUpdated : contained.meta.versionId.empty() and contained.meta.lastUpdated.empty()
dom-5	error	ClinicalUseDefinition	If a resource is contained in another resource, it SHALL NOT have a security label : contained.meta.security.empty()
dom-6	best practice	ClinicalUseDefinition	A resource should have narrative for robust management : text.`div`.exists()
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children : hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both : extension.exists() != value.exists()

Summary

Mandatory: 1 element(16 nested mandatory elements)

Structures

This structure refers to these other structures:

• IDMP MedicinalProductDefinition (http://fhir.ch/ig/ch-epl/StructureDefinition/ch-idmp-medicinalproductdefinition)

Slices

This structure defines the following Slices:

• The element 1 is sliced based on the value of ClinicalUseDefinition.indication.diseaseSymptomProcedure.concept.coding
• The element 1 is sliced based on the value of ClinicalUseDefinition.indication.comorbidity.concept.coding
• The element 1 is sliced based on the value of ClinicalUseDefinition.indication.intendedEffect.concept.coding