@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-cogallstaging> a fhir:CodeSystem;
  fhir:nodeRole fhir:treeRoot;
  fhir:Resource.id [ fhir:value "nkrs-cogallstaging"];
  fhir:DomainResource.text [
     fhir:Narrative.status [ fhir:value "generated" ];
     fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>This code system http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-cogallstaging defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style=\"white-space:nowrap\">CNS1<a name=\"nkrs-cogallstaging-CNS1\"> </a></td><td>CNS1</td><td>No blasts in the CSF, regardless of WBC and RBC.</td></tr><tr><td style=\"white-space:nowrap\">CNS2<a name=\"nkrs-cogallstaging-CNS2\"> </a></td><td>CNS2</td><td>CNS2, not otherwise specified</td></tr><tr><td style=\"white-space:nowrap\">CNS2a<a name=\"nkrs-cogallstaging-CNS2a\"> </a></td><td>CNS2a</td><td>&lt;5 WBC/µL + blasts + &lt;10 RBC/µL.</td></tr><tr><td style=\"white-space:nowrap\">CNS2b<a name=\"nkrs-cogallstaging-CNS2b\"> </a></td><td>CNS2b</td><td>&lt;5 WBC/µL + blasts + ≥10 RBC/µL</td></tr><tr><td style=\"white-space:nowrap\">CNS2c<a name=\"nkrs-cogallstaging-CNS2c\"> </a></td><td>CNS2c</td><td>≥5 WBC/µL + blasts + ≥10 RBC/µL, excess WBC proportional to RBC</td></tr><tr><td style=\"white-space:nowrap\">CNS3<a name=\"nkrs-cogallstaging-CNS3\"> </a></td><td>CNS3</td><td>CNS3, not otherwise specified</td></tr><tr><td style=\"white-space:nowrap\">CNS3a<a name=\"nkrs-cogallstaging-CNS3a\"> </a></td><td>CNS3a</td><td>≥5 WBC/µL + blasts + &lt;10 RBC/µL</td></tr><tr><td style=\"white-space:nowrap\">CNS3b<a name=\"nkrs-cogallstaging-CNS3b\"> </a></td><td>CNS3b</td><td>≥5 WBC/µL + blasts + ≥10 RBC/µL, excess WBC not proportional to RBC</td></tr><tr><td style=\"white-space:nowrap\">CNS3c<a name=\"nkrs-cogallstaging-CNS3c\"> </a></td><td>CNS3c</td><td>Clinical signs of CNS involvement.</td></tr></table></div>"
  ];
  fhir:CodeSystem.url [ fhir:value "http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-cogallstaging"];
  fhir:CodeSystem.version [ fhir:value "0.9.0"];
  fhir:CodeSystem.name [ fhir:value "NkrsCOGALLStaging"];
  fhir:CodeSystem.title [ fhir:value "NKRS - COG ALL Staging"];
  fhir:CodeSystem.status [ fhir:value "active"];
  fhir:CodeSystem.date [ fhir:value "2022-02-04T14:14:21+01:00"^^xsd:dateTime];
  fhir:CodeSystem.publisher [ fhir:value "Bundesamt für Gesundheit BAG"];
  fhir:CodeSystem.contact [
     fhir:index 0;
     fhir:ContactDetail.name [ fhir:value "Bundesamt für Gesundheit BAG" ];
     fhir:ContactDetail.telecom [
       fhir:index 0;
       fhir:ContactPoint.system [ fhir:value "url" ];
       fhir:ContactPoint.value [ fhir:value "https://www.bag.admin.ch/" ]
     ]
  ];
  fhir:CodeSystem.description [ fhir:value "COG ALL staging (for childhood B- precursor acute lymphoblastic leukemia, B-ALL) allows a uniform assessment \r\nof the extent of CNS involvement based on presence of blasts in the diagnostic cerebrospinal fluid (CSF). \r\n\r\n**COG ALL staging (Variable number: 4.20)** \r\nin \\'NATIONAL CANCER DATA DICTIONARY, V 1.1, Part A, BASIC VARIABLES for Adults, Adolescents, and Children (23.12.2019)\\'\r\n([EN](https://www.nacr.ch/assets/files/uploads/a-datadictionary-basicvariables-v1.1.pdf), \r\n[DE](https://www.nkrs.ch/assets/files/uploads/a-datenstruktur-variablen-der-basisdaten-v1.1.pdf), \r\n[FR](https://www.onec.ch/assets/files/uploads/a-dict-des-donnees-variables-de-base-v1.1.pdf), \r\n[IT](https://www.snrt.ch/assets/files/uploads/a-dati-oncologici-variabili-di-base-v1.1.pdf))"];
  fhir:CodeSystem.jurisdiction [
     fhir:index 0;
     fhir:CodeableConcept.coding [
       fhir:index 0;
       fhir:Coding.system [ fhir:value "urn:iso:std:iso:3166" ];
       fhir:Coding.code [ fhir:value "CH" ]
     ]
  ];
  fhir:CodeSystem.copyright [ fhir:value "CC-BY-SA-4.0"];
  fhir:CodeSystem.caseSensitive [ fhir:value "true"^^xsd:boolean];
  fhir:CodeSystem.valueSet [
     fhir:value "http://fhir.ch/ig/ch-crl/ValueSet/nkrs-cogallstaging";
     fhir:link <http://fhir.ch/ig/ch-crl/ValueSet/nkrs-cogallstaging>
  ];
  fhir:CodeSystem.content [ fhir:value "complete"];
  fhir:CodeSystem.count [ fhir:value "9"^^xsd:nonNegativeInteger];
  fhir:CodeSystem.concept [
     fhir:index 0;
     fhir:CodeSystem.concept.code [ fhir:value "CNS1" ];
     fhir:CodeSystem.concept.display [ fhir:value "CNS1" ];
     fhir:CodeSystem.concept.definition [ fhir:value "No blasts in the CSF, regardless of WBC and RBC." ]
  ], [
     fhir:index 1;
     fhir:CodeSystem.concept.code [ fhir:value "CNS2" ];
     fhir:CodeSystem.concept.display [ fhir:value "CNS2" ];
     fhir:CodeSystem.concept.definition [ fhir:value "CNS2, not otherwise specified" ]
  ], [
     fhir:index 2;
     fhir:CodeSystem.concept.code [ fhir:value "CNS2a" ];
     fhir:CodeSystem.concept.display [ fhir:value "CNS2a" ];
     fhir:CodeSystem.concept.definition [ fhir:value "<5 WBC/µL + blasts + <10 RBC/µL." ]
  ], [
     fhir:index 3;
     fhir:CodeSystem.concept.code [ fhir:value "CNS2b" ];
     fhir:CodeSystem.concept.display [ fhir:value "CNS2b" ];
     fhir:CodeSystem.concept.definition [ fhir:value "<5 WBC/µL + blasts + ≥10 RBC/µL" ]
  ], [
     fhir:index 4;
     fhir:CodeSystem.concept.code [ fhir:value "CNS2c" ];
     fhir:CodeSystem.concept.display [ fhir:value "CNS2c" ];
     fhir:CodeSystem.concept.definition [ fhir:value "≥5 WBC/µL + blasts + ≥10 RBC/µL, excess WBC proportional to RBC" ]
  ], [
     fhir:index 5;
     fhir:CodeSystem.concept.code [ fhir:value "CNS3" ];
     fhir:CodeSystem.concept.display [ fhir:value "CNS3" ];
     fhir:CodeSystem.concept.definition [ fhir:value "CNS3, not otherwise specified" ]
  ], [
     fhir:index 6;
     fhir:CodeSystem.concept.code [ fhir:value "CNS3a" ];
     fhir:CodeSystem.concept.display [ fhir:value "CNS3a" ];
     fhir:CodeSystem.concept.definition [ fhir:value "≥5 WBC/µL + blasts + <10 RBC/µL" ]
  ], [
     fhir:index 7;
     fhir:CodeSystem.concept.code [ fhir:value "CNS3b" ];
     fhir:CodeSystem.concept.display [ fhir:value "CNS3b" ];
     fhir:CodeSystem.concept.definition [ fhir:value "≥5 WBC/µL + blasts + ≥10 RBC/µL, excess WBC not proportional to RBC" ]
  ], [
     fhir:index 8;
     fhir:CodeSystem.concept.code [ fhir:value "CNS3c" ];
     fhir:CodeSystem.concept.display [ fhir:value "CNS3c" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Clinical signs of CNS involvement." ]
  ] .

# - ontology header ------------------------------------------------------------

<http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-cogallstaging.ttl> a owl:Ontology;
  owl:imports fhir:fhir.ttl .

# -------------------------------------------------------------------------------------