@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-whogradegroup> a fhir:CodeSystem;
  fhir:nodeRole fhir:treeRoot;
  fhir:Resource.id [ fhir:value "nkrs-whogradegroup"];
  fhir:DomainResource.text [
     fhir:Narrative.status [ fhir:value "generated" ];
     fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>This code system http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-whogradegroup defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style=\"white-space:nowrap\">1<a name=\"nkrs-whogradegroup-1\"> </a></td><td>Grade group 1</td><td>Gleason score ≤ 6 (≤ 3+3). \r\nOnly individual discrete well-formed glands.</td></tr><tr><td style=\"white-space:nowrap\">2<a name=\"nkrs-whogradegroup-2\"> </a></td><td>Grade group 2</td><td>Gleason score 7 (3 + 4). \r\nPredominantly well-formed glands with lesser component of poorly formed/fused/cribriform glands.</td></tr><tr><td style=\"white-space:nowrap\">3<a name=\"nkrs-whogradegroup-3\"> </a></td><td>Grade group 3</td><td>Gleason score 7 (4 + 3). \r\nPredominantly poorly formed/fused/cribriform glands with lesser component of well-formed glands.</td></tr><tr><td style=\"white-space:nowrap\">4<a name=\"nkrs-whogradegroup-4\"> </a></td><td>Grade group 4</td><td>Gleason score 8 (4 + 4 or 3 + 5 or 5 + 3).\r\nOnly poorly formed/fused/cribriform glands or\r\npredominantly well-formed glands and lesser component lacking glands or\r\npredominantly lacking glands and lesser component of well-formed glands.</td></tr><tr><td style=\"white-space:nowrap\">5<a name=\"nkrs-whogradegroup-5\"> </a></td><td>Grade group 5</td><td>Gleason score 9-10. \r\nLack of gland formation (or with necrosis) with or without poorly formed/fused/cribriform glands.</td></tr></table></div>"
  ];
  fhir:CodeSystem.url [ fhir:value "http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-whogradegroup"];
  fhir:CodeSystem.version [ fhir:value "0.9.0"];
  fhir:CodeSystem.name [ fhir:value "NkrsWHOGradeGroup"];
  fhir:CodeSystem.title [ fhir:value "NKRS - WHO Grade Group"];
  fhir:CodeSystem.status [ fhir:value "active"];
  fhir:CodeSystem.date [ fhir:value "2022-02-04T14:14:21+01:00"^^xsd:dateTime];
  fhir:CodeSystem.publisher [ fhir:value "Bundesamt für Gesundheit BAG"];
  fhir:CodeSystem.contact [
     fhir:index 0;
     fhir:ContactDetail.name [ fhir:value "Bundesamt für Gesundheit BAG" ];
     fhir:ContactDetail.telecom [
       fhir:index 0;
       fhir:ContactPoint.system [ fhir:value "url" ];
       fhir:ContactPoint.value [ fhir:value "https://www.bag.admin.ch/" ]
     ]
  ];
  fhir:CodeSystem.description [ fhir:value "A five-grade group system based on the grading categories from Gleason score 2 to 10. \r\n\r\n**WHO grade group (Variable number: 5.2.7)** \r\nin \\'NATIONAL CANCER DATA DICTIONARY, V 1.1, Part A, BASIC VARIABLES for Adults, Adolescents, and Children (23.12.2019)\\'\r\n([EN](https://www.nacr.ch/assets/files/uploads/a-datadictionary-basicvariables-v1.1.pdf), \r\n[DE](https://www.nkrs.ch/assets/files/uploads/a-datenstruktur-variablen-der-basisdaten-v1.1.pdf), \r\n[FR](https://www.onec.ch/assets/files/uploads/a-dict-des-donnees-variables-de-base-v1.1.pdf), \r\n[IT](https://www.snrt.ch/assets/files/uploads/a-dati-oncologici-variabili-di-base-v1.1.pdf))"];
  fhir:CodeSystem.jurisdiction [
     fhir:index 0;
     fhir:CodeableConcept.coding [
       fhir:index 0;
       fhir:Coding.system [ fhir:value "urn:iso:std:iso:3166" ];
       fhir:Coding.code [ fhir:value "CH" ]
     ]
  ];
  fhir:CodeSystem.copyright [ fhir:value "CC-BY-SA-4.0"];
  fhir:CodeSystem.caseSensitive [ fhir:value "true"^^xsd:boolean];
  fhir:CodeSystem.valueSet [
     fhir:value "http://fhir.ch/ig/ch-crl/ValueSet/nkrs-whogradegroup";
     fhir:link <http://fhir.ch/ig/ch-crl/ValueSet/nkrs-whogradegroup>
  ];
  fhir:CodeSystem.content [ fhir:value "complete"];
  fhir:CodeSystem.count [ fhir:value "5"^^xsd:nonNegativeInteger];
  fhir:CodeSystem.concept [
     fhir:index 0;
     fhir:CodeSystem.concept.code [ fhir:value "1" ];
     fhir:CodeSystem.concept.display [ fhir:value "Grade group 1" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Gleason score ≤ 6 (≤ 3+3). \r\nOnly individual discrete well-formed glands." ]
  ], [
     fhir:index 1;
     fhir:CodeSystem.concept.code [ fhir:value "2" ];
     fhir:CodeSystem.concept.display [ fhir:value "Grade group 2" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Gleason score 7 (3 + 4). \r\nPredominantly well-formed glands with lesser component of poorly formed/fused/cribriform glands." ]
  ], [
     fhir:index 2;
     fhir:CodeSystem.concept.code [ fhir:value "3" ];
     fhir:CodeSystem.concept.display [ fhir:value "Grade group 3" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Gleason score 7 (4 + 3). \r\nPredominantly poorly formed/fused/cribriform glands with lesser component of well-formed glands." ]
  ], [
     fhir:index 3;
     fhir:CodeSystem.concept.code [ fhir:value "4" ];
     fhir:CodeSystem.concept.display [ fhir:value "Grade group 4" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Gleason score 8 (4 + 4 or 3 + 5 or 5 + 3).\r\nOnly poorly formed/fused/cribriform glands or\r\npredominantly well-formed glands and lesser component lacking glands or\r\npredominantly lacking glands and lesser component of well-formed glands." ]
  ], [
     fhir:index 4;
     fhir:CodeSystem.concept.code [ fhir:value "5" ];
     fhir:CodeSystem.concept.display [ fhir:value "Grade group 5" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Gleason score 9-10. \r\nLack of gland formation (or with necrosis) with or without poorly formed/fused/cribriform glands." ]
  ] .

# - ontology header ------------------------------------------------------------

<http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-whogradegroup.ttl> a owl:Ontology;
  owl:imports fhir:fhir.ttl .

# -------------------------------------------------------------------------------------