@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-shimadagradingsystem> a fhir:CodeSystem;
  fhir:nodeRole fhir:treeRoot;
  fhir:Resource.id [ fhir:value "nkrs-shimadagradingsystem"];
  fhir:DomainResource.text [
     fhir:Narrative.status [ fhir:value "generated" ];
     fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>This code system http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-shimadagradingsystem defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style=\"white-space:nowrap\">1<a name=\"nkrs-shimadagradingsystem-1\"> </a></td><td>Favourable Histology</td><td>Age &lt;1.5 yrs: Poorly differentiated or differentiating and low or intermediate MKI tumor. / \r\nAge 1.5–5.0 yrs: Differentiating and low MKI tumor.</td></tr><tr><td style=\"white-space:nowrap\">2<a name=\"nkrs-shimadagradingsystem-2\"> </a></td><td>Unfavourable Histology</td><td>Age &lt; 1.5 yrs 1) Undifferentiated tumor; 2) high MKI (mitosis-karyorrhexis index) tumor. / \r\nAge 1.5–5.0 yrs 1) Undifferentiated and/or high MKI tumour 2) poorly differentiated and/or intermediate MKI tumour. / \r\nAge &gt; 5.0 yrs: All tumors.</td></tr></table></div>"
  ];
  fhir:CodeSystem.url [ fhir:value "http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-shimadagradingsystem"];
  fhir:CodeSystem.version [ fhir:value "0.9.0"];
  fhir:CodeSystem.name [ fhir:value "NkrsShimadaGradingSystem"];
  fhir:CodeSystem.title [ fhir:value "NKRS - Shimada Grading System"];
  fhir:CodeSystem.status [ fhir:value "active"];
  fhir:CodeSystem.date [ fhir:value "2022-02-04T14:14:21+01:00"^^xsd:dateTime];
  fhir:CodeSystem.publisher [ fhir:value "Bundesamt für Gesundheit BAG"];
  fhir:CodeSystem.contact [
     fhir:index 0;
     fhir:ContactDetail.name [ fhir:value "Bundesamt für Gesundheit BAG" ];
     fhir:ContactDetail.telecom [
       fhir:index 0;
       fhir:ContactPoint.system [ fhir:value "url" ];
       fhir:ContactPoint.value [ fhir:value "https://www.bag.admin.ch/" ]
     ]
  ];
  fhir:CodeSystem.description [ fhir:value "This data item records the grade for neuroblastoma, a frequent childhood cancer. Based on a grade of \r\nneuroblastic differentiation and mitosis-karyorrhexis index [MKI]) along with patient age at the time of diagnosis. \r\n\r\n**Shimada grading system (Variable number: 4.37)** \r\nin \\'NATIONAL CANCER DATA DICTIONARY, V 1.1, Part A, BASIC VARIABLES for Adults, Adolescents, and Children (23.12.2019)\\'\r\n([EN](https://www.nacr.ch/assets/files/uploads/a-datadictionary-basicvariables-v1.1.pdf), \r\n[DE](https://www.nkrs.ch/assets/files/uploads/a-datenstruktur-variablen-der-basisdaten-v1.1.pdf), \r\n[FR](https://www.onec.ch/assets/files/uploads/a-dict-des-donnees-variables-de-base-v1.1.pdf), \r\n[IT](https://www.snrt.ch/assets/files/uploads/a-dati-oncologici-variabili-di-base-v1.1.pdf))"];
  fhir:CodeSystem.jurisdiction [
     fhir:index 0;
     fhir:CodeableConcept.coding [
       fhir:index 0;
       fhir:Coding.system [ fhir:value "urn:iso:std:iso:3166" ];
       fhir:Coding.code [ fhir:value "CH" ]
     ]
  ];
  fhir:CodeSystem.copyright [ fhir:value "CC-BY-SA-4.0"];
  fhir:CodeSystem.caseSensitive [ fhir:value "true"^^xsd:boolean];
  fhir:CodeSystem.valueSet [
     fhir:value "http://fhir.ch/ig/ch-crl/ValueSet/nkrs-shimadagradingsystem";
     fhir:link <http://fhir.ch/ig/ch-crl/ValueSet/nkrs-shimadagradingsystem>
  ];
  fhir:CodeSystem.content [ fhir:value "complete"];
  fhir:CodeSystem.count [ fhir:value "2"^^xsd:nonNegativeInteger];
  fhir:CodeSystem.concept [
     fhir:index 0;
     fhir:CodeSystem.concept.code [ fhir:value "1" ];
     fhir:CodeSystem.concept.display [ fhir:value "Favourable Histology" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Age <1.5 yrs: Poorly differentiated or differentiating and low or intermediate MKI tumor. / \r\nAge 1.5–5.0 yrs: Differentiating and low MKI tumor." ]
  ], [
     fhir:index 1;
     fhir:CodeSystem.concept.code [ fhir:value "2" ];
     fhir:CodeSystem.concept.display [ fhir:value "Unfavourable Histology" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Age < 1.5 yrs 1) Undifferentiated tumor; 2) high MKI (mitosis-karyorrhexis index) tumor. / \r\nAge 1.5–5.0 yrs 1) Undifferentiated and/or high MKI tumour 2) poorly differentiated and/or intermediate MKI tumour. / \r\nAge > 5.0 yrs: All tumors." ]
  ] .

# - ontology header ------------------------------------------------------------

<http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-shimadagradingsystem.ttl> a owl:Ontology;
  owl:imports fhir:fhir.ttl .

# -------------------------------------------------------------------------------------