@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-irssstaging> a fhir:CodeSystem;
  fhir:nodeRole fhir:treeRoot;
  fhir:Resource.id [ fhir:value "nkrs-irssstaging"];
  fhir:DomainResource.text [
     fhir:Narrative.status [ fhir:value "generated" ];
     fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>This code system http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-irssstaging defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style=\"white-space:nowrap\">0<a name=\"nkrs-irssstaging-0\"> </a></td><td>Stage 0</td><td>Patients treated conservatively. The tumour is confined to the globe. Enucleation has not been performed.</td></tr><tr><td style=\"white-space:nowrap\">pI<a name=\"nkrs-irssstaging-pI\"> </a></td><td>pStage I</td><td>Eye enucleated, completely resected histologically</td></tr><tr><td style=\"white-space:nowrap\">pII<a name=\"nkrs-irssstaging-pII\"> </a></td><td>pStage II</td><td>Eye enucleated, microscopic residual tumour</td></tr><tr><td style=\"white-space:nowrap\">pIIIa<a name=\"nkrs-irssstaging-pIIIa\"> </a></td><td>pStage IIIa</td><td>Regional extension: overt orbital disease</td></tr><tr><td style=\"white-space:nowrap\">pIIIb<a name=\"nkrs-irssstaging-pIIIb\"> </a></td><td>pStage IIIb</td><td>Regional extension: preauricular or cervical lymph node extension</td></tr><tr><td style=\"white-space:nowrap\">cIVa.1<a name=\"nkrs-irssstaging-cIVa.461\"> </a></td><td>cStage IVa.1</td><td>Haematogenous metastasis (without CNS involvement): single lesion</td></tr><tr><td style=\"white-space:nowrap\">cIVa.2<a name=\"nkrs-irssstaging-cIVa.462\"> </a></td><td>cStage IVa.2</td><td>Haematogenous metastasis (without CNS involvement): multiple lesions</td></tr><tr><td style=\"white-space:nowrap\">cIVb.1<a name=\"nkrs-irssstaging-cIVb.461\"> </a></td><td>cStage IVb.1</td><td>CNS extension (with or without any other site of regional or metastatic disease: prechiasmatic lesion</td></tr><tr><td style=\"white-space:nowrap\">cIVb.2<a name=\"nkrs-irssstaging-cIVb.462\"> </a></td><td>cStage IVb.2</td><td>CNS extension (with or without any other site of regional or metastatic disease: CNS mass</td></tr><tr><td style=\"white-space:nowrap\">cIVb.3<a name=\"nkrs-irssstaging-cIVb.463\"> </a></td><td>cStage IVb.3</td><td>CNS extension (with or without any other site of regional or metastatic disease: leptomeningeal and cerebrospinal fluid disease</td></tr></table></div>"
  ];
  fhir:CodeSystem.url [ fhir:value "http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-irssstaging"];
  fhir:CodeSystem.version [ fhir:value "0.9.0"];
  fhir:CodeSystem.name [ fhir:value "NkrsIRSSStaging"];
  fhir:CodeSystem.title [ fhir:value "NKRS - IRSS Staging"];
  fhir:CodeSystem.status [ fhir:value "active"];
  fhir:CodeSystem.date [ fhir:value "2022-02-04T14:14:21+01:00"^^xsd:dateTime];
  fhir:CodeSystem.publisher [ fhir:value "Bundesamt für Gesundheit BAG"];
  fhir:CodeSystem.contact [
     fhir:index 0;
     fhir:ContactDetail.name [ fhir:value "Bundesamt für Gesundheit BAG" ];
     fhir:ContactDetail.telecom [
       fhir:index 0;
       fhir:ContactPoint.system [ fhir:value "url" ];
       fhir:ContactPoint.value [ fhir:value "https://www.bag.admin.ch/" ]
     ]
  ];
  fhir:CodeSystem.description [ fhir:value "The paediatric International Retinoblastoma Staging System is based on extent \r\nof disease and the presence of overt extra-ocular extension after enucleation. \r\n\r\n**IRSS staging (Variable number: 4.23)** \r\nin \\'NATIONAL CANCER DATA DICTIONARY, V 1.1, Part A, BASIC VARIABLES for Adults, Adolescents, and Children (23.12.2019)\\'\r\n([EN](https://www.nacr.ch/assets/files/uploads/a-datadictionary-basicvariables-v1.1.pdf), \r\n[DE](https://www.nkrs.ch/assets/files/uploads/a-datenstruktur-variablen-der-basisdaten-v1.1.pdf), \r\n[FR](https://www.onec.ch/assets/files/uploads/a-dict-des-donnees-variables-de-base-v1.1.pdf), \r\n[IT](https://www.snrt.ch/assets/files/uploads/a-dati-oncologici-variabili-di-base-v1.1.pdf))"];
  fhir:CodeSystem.jurisdiction [
     fhir:index 0;
     fhir:CodeableConcept.coding [
       fhir:index 0;
       fhir:Coding.system [ fhir:value "urn:iso:std:iso:3166" ];
       fhir:Coding.code [ fhir:value "CH" ]
     ]
  ];
  fhir:CodeSystem.copyright [ fhir:value "CC-BY-SA-4.0"];
  fhir:CodeSystem.caseSensitive [ fhir:value "true"^^xsd:boolean];
  fhir:CodeSystem.valueSet [
     fhir:value "http://fhir.ch/ig/ch-crl/ValueSet/nkrs-irssstaging";
     fhir:link <http://fhir.ch/ig/ch-crl/ValueSet/nkrs-irssstaging>
  ];
  fhir:CodeSystem.content [ fhir:value "complete"];
  fhir:CodeSystem.count [ fhir:value "10"^^xsd:nonNegativeInteger];
  fhir:CodeSystem.concept [
     fhir:index 0;
     fhir:CodeSystem.concept.code [ fhir:value "0" ];
     fhir:CodeSystem.concept.display [ fhir:value "Stage 0" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Patients treated conservatively. The tumour is confined to the globe. Enucleation has not been performed." ]
  ], [
     fhir:index 1;
     fhir:CodeSystem.concept.code [ fhir:value "pI" ];
     fhir:CodeSystem.concept.display [ fhir:value "pStage I" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Eye enucleated, completely resected histologically" ]
  ], [
     fhir:index 2;
     fhir:CodeSystem.concept.code [ fhir:value "pII" ];
     fhir:CodeSystem.concept.display [ fhir:value "pStage II" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Eye enucleated, microscopic residual tumour" ]
  ], [
     fhir:index 3;
     fhir:CodeSystem.concept.code [ fhir:value "pIIIa" ];
     fhir:CodeSystem.concept.display [ fhir:value "pStage IIIa" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Regional extension: overt orbital disease" ]
  ], [
     fhir:index 4;
     fhir:CodeSystem.concept.code [ fhir:value "pIIIb" ];
     fhir:CodeSystem.concept.display [ fhir:value "pStage IIIb" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Regional extension: preauricular or cervical lymph node extension" ]
  ], [
     fhir:index 5;
     fhir:CodeSystem.concept.code [ fhir:value "cIVa.1" ];
     fhir:CodeSystem.concept.display [ fhir:value "cStage IVa.1" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Haematogenous metastasis (without CNS involvement): single lesion" ]
  ], [
     fhir:index 6;
     fhir:CodeSystem.concept.code [ fhir:value "cIVa.2" ];
     fhir:CodeSystem.concept.display [ fhir:value "cStage IVa.2" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Haematogenous metastasis (without CNS involvement): multiple lesions" ]
  ], [
     fhir:index 7;
     fhir:CodeSystem.concept.code [ fhir:value "cIVb.1" ];
     fhir:CodeSystem.concept.display [ fhir:value "cStage IVb.1" ];
     fhir:CodeSystem.concept.definition [ fhir:value "CNS extension (with or without any other site of regional or metastatic disease: prechiasmatic lesion" ]
  ], [
     fhir:index 8;
     fhir:CodeSystem.concept.code [ fhir:value "cIVb.2" ];
     fhir:CodeSystem.concept.display [ fhir:value "cStage IVb.2" ];
     fhir:CodeSystem.concept.definition [ fhir:value "CNS extension (with or without any other site of regional or metastatic disease: CNS mass" ]
  ], [
     fhir:index 9;
     fhir:CodeSystem.concept.code [ fhir:value "cIVb.3" ];
     fhir:CodeSystem.concept.display [ fhir:value "cStage IVb.3" ];
     fhir:CodeSystem.concept.definition [ fhir:value "CNS extension (with or without any other site of regional or metastatic disease: leptomeningeal and cerebrospinal fluid disease" ]
  ] .

# - ontology header ------------------------------------------------------------

<http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-irssstaging.ttl> a owl:Ontology;
  owl:imports fhir:fhir.ttl .

# -------------------------------------------------------------------------------------