@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-icdo3histologicalgrade> a fhir:CodeSystem;
  fhir:nodeRole fhir:treeRoot;
  fhir:Resource.id [ fhir:value "nkrs-icdo3histologicalgrade"];
  fhir:DomainResource.text [
     fhir:Narrative.status [ fhir:value "generated" ];
     fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p>This code system http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-icdo3histologicalgrade defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style=\"white-space:nowrap\">1<a name=\"nkrs-icdo3histologicalgrade-1\"> </a></td><td>Grade I</td><td>Well differentiated; Differentiated, NOS; Low grade</td></tr><tr><td style=\"white-space:nowrap\">2<a name=\"nkrs-icdo3histologicalgrade-2\"> </a></td><td>Grade II</td><td>Moderately (well) differentiated; Intermediate differentiation.</td></tr><tr><td style=\"white-space:nowrap\">3<a name=\"nkrs-icdo3histologicalgrade-3\"> </a></td><td>Grade III</td><td>Poorly differentiated; Dedifferentiated; High grade.</td></tr><tr><td style=\"white-space:nowrap\">4<a name=\"nkrs-icdo3histologicalgrade-4\"> </a></td><td>Grade IV</td><td>Undifferentiated; Anaplastic.</td></tr><tr><td style=\"white-space:nowrap\">5<a name=\"nkrs-icdo3histologicalgrade-5\"> </a></td><td>T-cell</td><td>T-cell; T-precursor.</td></tr><tr><td style=\"white-space:nowrap\">6<a name=\"nkrs-icdo3histologicalgrade-6\"> </a></td><td>B-cell</td><td>B-cell; Pre-B; B-precursor.</td></tr><tr><td style=\"white-space:nowrap\">7<a name=\"nkrs-icdo3histologicalgrade-7\"> </a></td><td>Null cell</td><td>Null cell; Non-T-non-B.</td></tr><tr><td style=\"white-space:nowrap\">8<a name=\"nkrs-icdo3histologicalgrade-8\"> </a></td><td>NK cell</td><td>NK cell; Natural killer cell.</td></tr></table></div>"
  ];
  fhir:CodeSystem.url [ fhir:value "http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-icdo3histologicalgrade"];
  fhir:CodeSystem.version [ fhir:value "0.9.0"];
  fhir:CodeSystem.name [ fhir:value "NkrsIcdO3HistologicalGrade"];
  fhir:CodeSystem.title [ fhir:value "NKRS - ICD-O-3 Histological Grade"];
  fhir:CodeSystem.status [ fhir:value "active"];
  fhir:CodeSystem.date [ fhir:value "2022-02-04T14:14:21+01:00"^^xsd:dateTime];
  fhir:CodeSystem.publisher [ fhir:value "Bundesamt für Gesundheit BAG"];
  fhir:CodeSystem.contact [
     fhir:index 0;
     fhir:ContactDetail.name [ fhir:value "Bundesamt für Gesundheit BAG" ];
     fhir:ContactDetail.telecom [
       fhir:index 0;
       fhir:ContactPoint.system [ fhir:value "url" ];
       fhir:ContactPoint.value [ fhir:value "https://www.bag.admin.ch/" ]
     ]
  ];
  fhir:CodeSystem.description [ fhir:value "The data item describes the neoplasm’s resemblance to normal (parent) tissue according to ICD-O. \r\n\r\n**ICD-O Histological Grade (Variable number: 3.7)** \r\nin \\'NATIONAL CANCER DATA DICTIONARY, V 1.1, Part A, BASIC VARIABLES for Adults, Adolescents, and Children (23.12.2019)\\'\r\n([EN](https://www.nacr.ch/assets/files/uploads/a-datadictionary-basicvariables-v1.1.pdf), \r\n[DE](https://www.nkrs.ch/assets/files/uploads/a-datenstruktur-variablen-der-basisdaten-v1.1.pdf), \r\n[FR](https://www.onec.ch/assets/files/uploads/a-dict-des-donnees-variables-de-base-v1.1.pdf), \r\n[IT](https://www.snrt.ch/assets/files/uploads/a-dati-oncologici-variabili-di-base-v1.1.pdf))"];
  fhir:CodeSystem.jurisdiction [
     fhir:index 0;
     fhir:CodeableConcept.coding [
       fhir:index 0;
       fhir:Coding.system [ fhir:value "urn:iso:std:iso:3166" ];
       fhir:Coding.code [ fhir:value "CH" ]
     ]
  ];
  fhir:CodeSystem.copyright [ fhir:value "CC-BY-SA-4.0"];
  fhir:CodeSystem.caseSensitive [ fhir:value "true"^^xsd:boolean];
  fhir:CodeSystem.valueSet [
     fhir:value "http://fhir.ch/ig/ch-crl/ValueSet/nkrs-icdo3histologicalgrade";
     fhir:link <http://fhir.ch/ig/ch-crl/ValueSet/nkrs-icdo3histologicalgrade>
  ];
  fhir:CodeSystem.content [ fhir:value "complete"];
  fhir:CodeSystem.count [ fhir:value "8"^^xsd:nonNegativeInteger];
  fhir:CodeSystem.concept [
     fhir:index 0;
     fhir:CodeSystem.concept.code [ fhir:value "1" ];
     fhir:CodeSystem.concept.display [ fhir:value "Grade I" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Well differentiated; Differentiated, NOS; Low grade" ]
  ], [
     fhir:index 1;
     fhir:CodeSystem.concept.code [ fhir:value "2" ];
     fhir:CodeSystem.concept.display [ fhir:value "Grade II" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Moderately (well) differentiated; Intermediate differentiation." ]
  ], [
     fhir:index 2;
     fhir:CodeSystem.concept.code [ fhir:value "3" ];
     fhir:CodeSystem.concept.display [ fhir:value "Grade III" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Poorly differentiated; Dedifferentiated; High grade." ]
  ], [
     fhir:index 3;
     fhir:CodeSystem.concept.code [ fhir:value "4" ];
     fhir:CodeSystem.concept.display [ fhir:value "Grade IV" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Undifferentiated; Anaplastic." ]
  ], [
     fhir:index 4;
     fhir:CodeSystem.concept.code [ fhir:value "5" ];
     fhir:CodeSystem.concept.display [ fhir:value "T-cell" ];
     fhir:CodeSystem.concept.definition [ fhir:value "T-cell; T-precursor." ]
  ], [
     fhir:index 5;
     fhir:CodeSystem.concept.code [ fhir:value "6" ];
     fhir:CodeSystem.concept.display [ fhir:value "B-cell" ];
     fhir:CodeSystem.concept.definition [ fhir:value "B-cell; Pre-B; B-precursor." ]
  ], [
     fhir:index 6;
     fhir:CodeSystem.concept.code [ fhir:value "7" ];
     fhir:CodeSystem.concept.display [ fhir:value "Null cell" ];
     fhir:CodeSystem.concept.definition [ fhir:value "Null cell; Non-T-non-B." ]
  ], [
     fhir:index 7;
     fhir:CodeSystem.concept.code [ fhir:value "8" ];
     fhir:CodeSystem.concept.display [ fhir:value "NK cell" ];
     fhir:CodeSystem.concept.definition [ fhir:value "NK cell; Natural killer cell." ]
  ] .

# - ontology header ------------------------------------------------------------

<http://fhir.ch/ig/ch-crl/CodeSystem/nkrs-icdo3histologicalgrade.ttl> a owl:Ontology;
  owl:imports fhir:fhir.ttl .

# -------------------------------------------------------------------------------------